Title : Integration of new regulatory strategies into the network of an endocrine control system: limitation of androgen secretion by rat testis is achieved by substrate-dependent modulation of P450XVII enzyme concentration and catalytic efficiency.

Pub. Date : 1992 Mar-Apr

PMID : 1605399






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cytochrome P450XVII (steroid-17 alpha-monooxygenase/steroid-17,20-lyase), one key enzyme in steroid hormone biosynthesis, responds to external human choriogonadotropin stimulation with an oxygen-dependent and substrate flux-dependent inactivation and decomposition, and increased substrate availability decreases the efficiency of androgen formation in favour of abortive intermediate leakage. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens