Title : A local mechanism mediates NAD-dependent protection of axon degeneration.

Pub. Date : 2005 Aug 1

PMID : 16043516






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Important insight into the mechanisms of axon degeneration arose from findings that the degeneration of transected axons is delayed in Wallerian degeneration slow (Wlds) mice with the overexpression of a fusion protein with the nicotinamide adenine dinucleotide (NAD) synthetic enzyme, nicotinamide mononucleotide adenylyltransferase (Nmnat1). NAD nicotinamide nucleotide adenylyltransferase 1 Mus musculus
2 Furthermore, we provide evidence that such Nmnat1/NAD-mediated protection is primarily mediated by their effects on local bioenergetics. NAD nicotinamide nucleotide adenylyltransferase 1 Mus musculus