Title : The distribution and density of ET-1 and its receptors are different in human right and left ventricular endocardial endothelial cells.

Pub. Date : 2005 Aug

PMID : 16042982






3 Functional Relationships(s)
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1 In this study, we verified if the distribution and density of ET-1 and its receptors could be different in right as compared to left ventricular EECs, and whether this difference may affect ET-1-induced increase of intracellular calcium. Calcium endothelin 1 Homo sapiens
2 In this study, we verified if the distribution and density of ET-1 and its receptors could be different in right as compared to left ventricular EECs, and whether this difference may affect ET-1-induced increase of intracellular calcium. Calcium endothelin 1 Homo sapiens
3 Moreover, using the Fura-2 calcium measurement technique, our results showed that in left ventricular EECs, both ET(A) and ET(B) receptor activation mediated the effect of ET-1 on intracellular calcium, whereas in right ventricular EECs, this effect was solely mediated by the ET(A) receptor. Calcium endothelin 1 Homo sapiens