Title : In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia.

Pub. Date : 2005 Sep

PMID : 16038735






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1 In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
2 In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
3 Tumour cells with internal tandem duplication (ITD) in the FLT3 receptor gene were significantly more sensitive to the FLT3 inhibitor SU5614 than tumour cells with wild type FLT3. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
4 Tumour cells with internal tandem duplication (ITD) in the FLT3 receptor gene were significantly more sensitive to the FLT3 inhibitor SU5614 than tumour cells with wild type FLT3. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
5 Tumour cells with internal tandem duplication (ITD) in the FLT3 receptor gene were significantly more sensitive to the FLT3 inhibitor SU5614 than tumour cells with wild type FLT3. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
6 Our results suggest that the FLT3 inhibitor SU5614 may have a therapeutic potential, especially in combination with other cytotoxic agents, in patients with FLT3-ITD positive AML. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens
7 Our results suggest that the FLT3 inhibitor SU5614 may have a therapeutic potential, especially in combination with other cytotoxic agents, in patients with FLT3-ITD positive AML. SU 5614 fms related receptor tyrosine kinase 3 Homo sapiens