Pub. Date : 2005 Oct
PMID : 16037950
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | High-resolution immunogold electron microscopic immunocytochemistry was used to compare surface and intracellular labeling of the calcium sensitive AMPA GluR1 receptor subunit in the basolateral (BLA) and central (CeA) nuclei of the amygdala in rats self-administering escalating doses of morphine or saline. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | Morphine self-administration was associated with regionally diverse effects on dendritic GluR1 targeting in the BLA and CeA. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 4 | In the BLA of morphine self-administering animals, there was a significant increase in the proportion of immunogold particles for GluR1 on the plasma membrane of dendrites, particularly in association with extrasynaptic sites, which was most prominent in large (2-4 microm) profiles. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 5 | These results indicate that GluR1 targeting is a dynamic process that can be differentially affected in distinct amygdala regions in response to chronic self-administration of morphine. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |