Pub. Date : 2005 Oct
PMID : 16033816
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. | Tyrosine | suppressor of cytokine signaling 1 | Homo sapiens |
| 2 | Expression of SOCS3 or SOCS1, but not SOCS2 and cytokine-inducible SH2 domain-containing protein, completely suppressed G-CSF-induced Stat5 activation but had only a weak effect on Stat5 activation mediated by the receptor mutant lacking Tyr 729. | Tyrosine | suppressor of cytokine signaling 1 | Homo sapiens |
| 3 | SOCS1 and SOCS3 also inhibited G-CSF-dependent cell proliferation, but the inhibitory effect of the two SOCS proteins on cell proliferation was diminished when Tyr 729 of the G-CSF-R was mutated. | Tyrosine | suppressor of cytokine signaling 1 | Homo sapiens |
| 4 | These data indicate that Tyr 729 of the G-CSF-R is required for SOCS1- and SOCS3-mediated negative regulation of G-CSF-R signaling and that the duration and intensity of G-CSF-induced Stat5 activation are regulated by two distinct mechanisms. | Tyrosine | suppressor of cytokine signaling 1 | Homo sapiens |