Pub. Date : 2005 Aug
PMID : 16033398
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of nickel-induced T-cell responsiveness by CD4+CD25+ cells in contact allergic patients and healthy individuals. | Nickel | CD4 molecule | Homo sapiens |
| 2 | In this study, we investigated the capacity of CD4+CD25+ regulatory T cells to suppress nickel-specific effector T cells, both in nickel-allergic patients and healthy controls. | Nickel | CD4 molecule | Homo sapiens |
| 3 | CD4+ cells isolated from allergic patients showed an increased proliferative response to nickel, whereas CD4+ cells from negative controls did not respond to allergen. | Nickel | CD4 molecule | Homo sapiens |
| 4 | When CD4+CD25+ cells were depleted, nickel-specific responsiveness was strongly increased both in allergic and in non-allergic individuals, with the most pronounced effect in allergic patients. | Nickel | CD4 molecule | Homo sapiens |
| 5 | These regulatory T cells were anergic to nickel but inhibited nickel-specific CD4+CD25- effector T cells in coculture experiments. | Nickel | CD4 molecule | Homo sapiens |
| 6 | CD4+CD25+ cells from nickel-allergic patients showed only a limited capacity to suppress effector T-cell responsiveness, because an increased nickel reactivity could still be detected in these cocultures. | Nickel | CD4 molecule | Homo sapiens |
| 7 | CD4+CD25+ cells from nickel-allergic patients showed only a limited capacity to suppress effector T-cell responsiveness, because an increased nickel reactivity could still be detected in these cocultures. | Nickel | CD4 molecule | Homo sapiens |
| 8 | Overall, these results support the view that CD4+CD25+ cells can control the activation of nickel-specific effector T cells in non-allergic individuals, whereas this regulatory capacity is impaired in allergic patients. | Nickel | CD4 molecule | Homo sapiens |