Title : Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae.

Pub. Date : 2005 Sep 30

PMID : 16024909






1 Functional Relationships(s)
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1 Here we used a modeled structure of S. cerevisiae LTA4 hydrolase, mutational analysis, and binding studies to show that Glu-316 and Arg-627 are critical for catalysis, allowing us to a propose a mechanism for the epoxide hydrolase activity. Glutamic Acid leukotriene A4 hydrolase Homo sapiens