Title : Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase.

Pub. Date : 2005

PMID : 16024742






1 Functional Relationships(s)
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Protein Name
Organism
1 hOgg1 interacted with a substrate containing an aldehydic AP site very slowly, but the addition of 8-bromoguanine (8-BrG) greatly accelerated the reaction, which was best described by two initial equilibrium steps followed by one irreversible chemical step and a final product release equilibrium step. 8-bromoguanine 8-oxoguanine DNA glycosylase Homo sapiens