Pub. Date : 2005 Jul 15
PMID : 16024629
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Previous reports have linked the COX-2 product prostaglandin E2 (PGE2) to the abnormal activation of the mitogen-activated protein kinase/Erk kinase pathway. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Previous reports have linked the COX-2 product prostaglandin E2 (PGE2) to the abnormal activation of the mitogen-activated protein kinase/Erk kinase pathway. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Here we show that PGE2 is able to rapidly stimulate Erk phosphorylation in a subset of non-small cell lung cancer (NSCLC) cell lines. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Activation of the Erk pathway by PGE2 was also resistant to src kinase inhibitors but sensitive to the protein kinase C inhibition. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Selective inhibition of EP receptors revealed the possible involvement of Ca2+-dependent signaling in PGE2-mediated activation of Erk. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Our data indicate the presence of an EGFR-independent activation of the mitogen-activated protein kinase/Erk pathway by PGE2 in NSCLC cells. | Dinoprostone | mitogen-activated protein kinase 1 | Homo sapiens |