Title : Independent role of phosphoinositol-3-kinase (PI3K) and casein kinase II (CK-2) in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate cancer cells.

Pub. Date : 2005 Dec 1

PMID : 16015604






1 Functional Relationships(s)
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Protein Name
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1 EGFR activates NF-kappaB through the PI3K/Akt pathway that leads to the phosphorylation of IkappaBalpha on serines 32 and 36, thereby promoting the nuclear translocation of the p65 subunit. Serine epidermal growth factor receptor Homo sapiens