Pub. Date : 2005 Oct 20
PMID : 16007147
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. | betulinic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Thus, our findings that activation of NF-kappaB by BetA promotes BetA-induced apoptosis in a cell type-specific fashion indicate that NF-kappaB inhibitors in combination with BetA would have no therapeutic benefit or could even be contraproductive in certain tumors, which has important implications for the design of BetA-based combination protocols. | betulinic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Thus, our findings that activation of NF-kappaB by BetA promotes BetA-induced apoptosis in a cell type-specific fashion indicate that NF-kappaB inhibitors in combination with BetA would have no therapeutic benefit or could even be contraproductive in certain tumors, which has important implications for the design of BetA-based combination protocols. | betulinic acid | nuclear factor kappa B subunit 1 | Homo sapiens |