Title : Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.

Pub. Date : 2005 Jul 19

PMID : 16006525






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Chemical inducers such as sulforaphane are known to react with Keap1 cysteine residues, thereby promoting Nrf2 nuclear accumulation and hence ARE activation. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens
2 A widely accepted model for Nrf2 nuclear accumulation is that modification of Keap1 cysteines leads directly to dissociation of the Keap1-Nrf2 complex. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens
3 A widely accepted model for Nrf2 nuclear accumulation is that modification of Keap1 cysteines leads directly to dissociation of the Keap1-Nrf2 complex. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens