Title : Validation of the plasma half-life of 11alpha-deuterium cortisol as a sensitive index for the analysis of human 11beta-HSD2 activity in vivo.

Pub. Date : 2005 Nov

PMID : 16005482






1 Functional Relationships(s)
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1 Oral administration of 5mg of cortisol-(13)C(4),(2)H(1) to a human subject after repeated ingestions of 130mg/day of glycyrrhetinic acid for 5 days resulted in a decrease in the rate constant of the cortisol-(13)C(4),(2)H(1) to cortisone-(13)C(4) conversion, a direct index reflecting 11beta-HSD2 activity. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens