Pub. Date : 2005 Jun 30
PMID : 16000871
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the possibility that IL-6 signaling via the Jak-Stat pathway is modulated by 15d-PGJ(2) in lymphocytes and also examined whether the inhibition of IL-6 signaling is dependent of PPARgamma. | 15d-pgj | interleukin 6 | Homo sapiens |
| 2 | 15d-PGJ(2) blocked IL-6 induced Stat1 and Stat3 activation in primary human lymphocytes, Jurkat cells and immortalized rheumatoid arthritis B cells. | 15d-pgj | interleukin 6 | Homo sapiens |
| 3 | Inhibition of IL-6 signaling was induced rapidly within 15 min after treatment of 15d-PGJ(2). | 15d-pgj | interleukin 6 | Homo sapiens |
| 4 | Other PPARgamma-agonists, such as troglitazone and ciglitazone, did not inhibit IL-6 signaling, indicating that 15d-PGJ(2) affect the IL-6-induced Jak-Stat signaling pathway via PPARgamma-independent mechanism. | 15d-pgj | interleukin 6 | Homo sapiens |