Pub. Date : 2005 Jul 13
PMID : 15998135
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway. | epigallocatechin gallate | cyclin dependent kinase 2 | Homo sapiens |
| 2 | While EGCG was demonstrated to decrease Cdk2 expression and activity and increase caspase-3 activity, overexpression of Cdk2 and treatment with the caspase-3 inhibitor respectively prevented preadipocytes from induction of DNA fragmentation and caspase-3 activity by doses of 100-400 muM of EGCG. | epigallocatechin gallate | cyclin dependent kinase 2 | Homo sapiens |
| 3 | While EGCG was demonstrated to decrease Cdk2 expression and activity and increase caspase-3 activity, overexpression of Cdk2 and treatment with the caspase-3 inhibitor respectively prevented preadipocytes from induction of DNA fragmentation and caspase-3 activity by doses of 100-400 muM of EGCG. | epigallocatechin gallate | cyclin dependent kinase 2 | Homo sapiens |
| 4 | This suggests the Cdk2- and caspase-3-dependent apoptotic effects of EGCG. | epigallocatechin gallate | cyclin dependent kinase 2 | Homo sapiens |