Pub. Date : 2005 Oct 15
PMID : 15982677
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide. | Acrylamide | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide. | Acrylamide | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | In those experiments, dose-related increases in dominant lethal mutations were detected in uterine contents of female mice mated to acrylamide-treated wild-type males but not CYP2E1-null males, clearly implicating CYP2E1-mediated formation of glycidamide in the induction of genetic damage in male germ cells. | Acrylamide | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 4 | These results support the hypothesis that genetic damage in somatic and germ cells of mice-treated with acrylamide is dependent upon metabolism of the parent compound by CYP2E1. | Acrylamide | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |