Pub. Date : 2006 Feb
PMID : 15961274
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells. | Arsenic Trioxide | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Using reporter assay, RT-PCR and Western blotting, we show that c-Src activation might be a prerequisite for As2O3-induced EGFR/Ras/Raf/ERK signaling. | Arsenic Trioxide | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Taken together, we conclude that the Sp1 binding sites are required for As2O3-induced p21 gene transcription through c-Src/EGFR/Ras/Raf/ERK pathway. | Arsenic Trioxide | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |