Title : Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function.

Pub. Date : 2005 Jul

PMID : 15955561






2 Functional Relationships(s)
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1 FK506 and rapamycin are immunosuppressant drugs that disrupt the interaction of FK506-binding proteins (FKBPs) with ryanodine receptors (RyR1), which form homotetrameric Ca2+ release channels in the sarcoplasmic reticulum (SR) of skeletal muscle. Tacrolimus ryanodine receptor 1 Homo sapiens
2 FK506 and rapamycin are immunosuppressant drugs that disrupt the interaction of FK506-binding proteins (FKBPs) with ryanodine receptors (RyR1), which form homotetrameric Ca2+ release channels in the sarcoplasmic reticulum (SR) of skeletal muscle. Tacrolimus ryanodine receptor 1 Homo sapiens