Pub. Date : 2005 Aug
PMID : 15951320
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Tacrolimus is metabolized predominantly to 13-O-demethyltacrolimus in the liver and intestine by cytochrome P450 3A (CYP3A). | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | BACKGROUND: Tacrolimus is metabolized predominantly to 13-O-demethyltacrolimus in the liver and intestine by cytochrome P450 3A (CYP3A). | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Patients with high concentrations of CYP3A5, a CYP3A isoenzyme polymorphically produced in these organs, require higher doses of tacrolimus, but the exact mechanism of this association is unknown. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The importance of CYP3A5 status for tacrolimus clearance is also dependent on the concomitant CYP3A4 activity. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |