Title : The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions.

Pub. Date : 2005 Jun 30

PMID : 15950210






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Sulfhydryl Compounds glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
2 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Sulfhydryl Compounds glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
3 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Sulfhydryl Compounds glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
4 Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols. Sulfhydryl Compounds glyceraldehyde-3-phosphate dehydrogenase Homo sapiens