Title : DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.

Pub. Date : 2005 Jul 15

PMID : 15922304






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The domain A of HMGB1 (HMGB1a protein) binds to the adduct formed by the R enantiomer at the CGGA sequence with a similar high affinity as it does to the adduct of antitumor cisplatin, and to the adduct formed by the S enantiomer with a slightly lower affinity. Cisplatin high mobility group box 1 Homo sapiens