Title : Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

Pub. Date : 2005 Aug 1

PMID : 15919715






1 Functional Relationships(s)
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1 Taken together, these results show that phenformin and AICAR suppress amiloride-sensitive Na+ transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+ entry through ENaC and basolateral Na+ extrusion via the Na+,K+-ATPase. Amiloride protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens