Title : The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2).

Pub. Date : 2005 Sep

PMID : 15917434






5 Functional Relationships(s)
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Protein Name
Organism
1 Mrp2 protein was significantly increased in rats treated with PCN for 2 days but significantly decreased in 19-day pregnant rats relative to controls; no significant differences were observed in Mrp2 mRNA expression among these groups. Pregnenolone Carbonitrile ATP binding cassette subfamily C member 2 Rattus norvegicus
2 The measured half-lives of 14C-labeled Mrp2 in control, pregnant, and PCN-treated rats were 27, 36, and 22 h, respectively, and were not significantly different. Pregnenolone Carbonitrile ATP binding cassette subfamily C member 2 Rattus norvegicus
3 The rate of incorporation of 35S into Mrp2 was highest in PCN-treated rats. Pregnenolone Carbonitrile ATP binding cassette subfamily C member 2 Rattus norvegicus
4 Polysomal distribution analysis of Mrp2 mRNA was consistent with increased Mrp2 protein synthesis after PCN treatment. Pregnenolone Carbonitrile ATP binding cassette subfamily C member 2 Rattus norvegicus
5 Polysomal distribution analysis of Mrp2 mRNA was consistent with increased Mrp2 protein synthesis after PCN treatment. Pregnenolone Carbonitrile ATP binding cassette subfamily C member 2 Rattus norvegicus