Pub. Date : 2005 Sep
PMID : 15913932
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we investigated the signal transduction pathways of expression of IL-6 in the desferrioxamine (DFX)-stimulated cochlear auditory cell line, HEI-OC1 cells. | Deferoxamine | interleukin 6 | Homo sapiens |
| 2 | In the present study, we investigated the signal transduction pathways of expression of IL-6 in the desferrioxamine (DFX)-stimulated cochlear auditory cell line, HEI-OC1 cells. | Deferoxamine | interleukin 6 | Homo sapiens |
| 3 | DFX significantly increased the production of IL-6 (P<0.05) and expression of IL-6 mRNA but did not affect TNF-alpha production. | Deferoxamine | interleukin 6 | Homo sapiens |
| 4 | DFX significantly increased the production of IL-6 (P<0.05) and expression of IL-6 mRNA but did not affect TNF-alpha production. | Deferoxamine | interleukin 6 | Homo sapiens |
| 5 | Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 (about 72% inhibition, P=0.027) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125. | Deferoxamine | interleukin 6 | Homo sapiens |
| 6 | DFX also induced IL-6 production and HIF-1alpha expression in the inner ear. | Deferoxamine | interleukin 6 | Homo sapiens |
| 7 | We demonstrated the regulatory effects of MAPK, HIF-1alpha, and NF-kappaB on DFX-induced IL-6 production in a HEI-OC1 for the first time. | Deferoxamine | interleukin 6 | Homo sapiens |
| 8 | In conclusion, these data indicate that regulation of inflammatory cytokine IL-6 by DFX, through mimicking hypoxic conditions, might explain its beneficial effect in the treatment of hypoxia-induced inner ear diseases. | Deferoxamine | interleukin 6 | Homo sapiens |