Title : An in vivo evaluation of docetaxel delivered intratumorally in head and neck squamous cell carcinoma.

Pub. Date : 2005 May

PMID : 15897421






1 Functional Relationships(s)
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1 Supradose levels of docetaxel produced distinct protein expression patterns for regulators of the cell cycle (cyclins A and B, p21, and p27), apoptosis (cleaved caspase-3 and cleaved PARP), and signal transduction (EGFR, pEGFR, pc-Jun, and pERK) in HNSCC, which supports a distinctive mechanism of action for supradose docetaxel levels. Docetaxel epidermal growth factor receptor Homo sapiens