Title : Effects of naltrexone on the ethanol-induced changes in the rat central dopaminergic system.

Pub. Date : 2005 Jul-Aug

PMID : 15897221






4 Functional Relationships(s)
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1 We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone. Ethanol tyrosine hydroxylase Rattus norvegicus
2 We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone. Ethanol tyrosine hydroxylase Rattus norvegicus
3 RESULTS: Chronic ethanol consumption increased TH mRNA levels in the VTA, but did not cause any significant change in the SN. Ethanol tyrosine hydroxylase Rattus norvegicus
4 With naltrexone treatment, ethanol-induced increase in the TH mRNA level was reduced in the VTA. Ethanol tyrosine hydroxylase Rattus norvegicus