Title : Prolonged allogeneic islet graft survival by protoporphyrins.

Pub. Date : 2005

PMID : 15881418






3 Functional Relationships(s)
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1 We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet graft survival. Protoporphyrins heme oxygenase 1 Homo sapiens
2 We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet graft survival. Protoporphyrins heme oxygenase 1 Homo sapiens
3 Administration of protoporphyrins to the recipients of allogeneic islets also resulted in transient powerful immunosuppression with reduced lymphocyte proliferative responses, increased proportion of regulatory cells (CD4+CD25+), decreased mononuclear cell infiltrating the graft, paralleled by a systemic upregulation of HO-1 expression. Protoporphyrins heme oxygenase 1 Homo sapiens