Title : Investigating serpin-enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II.

Pub. Date : 2006

PMID : 15869786






3 Functional Relationships(s)
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1 HCII-IIa complexes of all P1 variants were stable in the absence of heparin, but those of the L444K and L444R variants released active IIa over time with heparin. Heparin serpin family D member 1 Homo sapiens
2 HCII-IIa complexes of all P1 variants were stable in the absence of heparin, but those of the L444K and L444R variants released active IIa over time with heparin. Heparin serpin family D member 1 Homo sapiens
3 This is the first description of HCII-IIa complexes of transient stability forming in the absence of heparin, and may explain the extent to which the reactive centre loop of HCII differs from that of AT. Heparin serpin family D member 1 Homo sapiens