Protein Name serpin family D member 1
Organism Homo sapiens
Gene ID 3053
Gene Symbol


UniProt P05546 (HEP2_HUMAN), Q8IVC0 (Q8IVC0_HUMAN)
Relationships Total Number of functionally related compound(s) : 187
Total Number of Articles : 182

serpin family D member 1

Gene Summary

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]

  • heparin cofactor 2
  • leuserpin 2
  • protease inhibitor leuserpin-2
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