Title : Impairment of stromelysin-1 transcriptional activity by promoter mutations in high microsatellite instability colorectal tumors.

Pub. Date : 2005 May 1

PMID : 15867378






3 Functional Relationships(s)
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1 In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcriptional activity of wild-type MMP-3 promoter was 10-fold higher than the mutants activity. Tetradecanoylphorbol Acetate matrix metallopeptidase 3 Homo sapiens
2 In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcriptional activity of wild-type MMP-3 promoter was 10-fold higher than the mutants activity. Tetradecanoylphorbol Acetate matrix metallopeptidase 3 Homo sapiens
3 Significantly, dexamethasone almost completely blunted the TPA-induced effect on wild-type MMP-3 promoter transcriptional activity and on the mutants, even below their basal activity. Tetradecanoylphorbol Acetate matrix metallopeptidase 3 Homo sapiens