Pub. Date : 2005 May 1
PMID : 15866483
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells. | Palmitates | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | Here, we report that exposure of C2C12 skeletal muscle cells to 0.75 mM palmitate reduced (74%, P<0.01) the mRNA levels of the PPARbeta/delta-target gene pyruvatedehydrogenase kinase 4 (PDK-4), which is involved in fatty acid utilization. | Palmitates | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | Increased NF-kappaB activity after palmitate exposure was associated with enhanced protein-protein interaction between PPARbeta/delta and p65. | Palmitates | peroxisome proliferator activator receptor delta | Mus musculus |
| 4 | These results indicate that palmitate may reduce fatty acid utilization in skeletal muscle cells by reducing PPARbeta/delta signaling through increased NF-kappaB activity. | Palmitates | peroxisome proliferator activator receptor delta | Mus musculus |