Title : Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways.

Pub. Date : 2005 Jul

PMID : 15845624






2 Functional Relationships(s)
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1 Coincubation of IGF-I with specific inhibitors of the p42/44 MAPK pathway (PD098059 or U0126) completely abolished the stimulatory effect of IGF-I on IGFBP-3 mRNA expression but did not affect increased IGFBP-5 mRNA levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin-like growth factor 1 Rattus norvegicus
2 Coincubation of IGF-I with specific inhibitors of the p42/44 MAPK pathway (PD098059 or U0126) completely abolished the stimulatory effect of IGF-I on IGFBP-3 mRNA expression but did not affect increased IGFBP-5 mRNA levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin-like growth factor 1 Rattus norvegicus