Title : Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.

Pub. Date : 2005 May

PMID : 15842554






4 Functional Relationships(s)
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1 AIMS: We evaluated the involvement of cytochrome P450 (CYP) isoforms 2C9 and 2C19 in chlorpropamide 2-hydroxylation in vitro and in chlorpropamide disposition in vivo. Chlorpropamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 AIMS: We evaluated the involvement of cytochrome P450 (CYP) isoforms 2C9 and 2C19 in chlorpropamide 2-hydroxylation in vitro and in chlorpropamide disposition in vivo. Chlorpropamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 METHODS: To identify CYP isoforms(s) that catalyse 2-hydroxylation of chlorpropamide, the incubation studies were conducted using human liver microsomes and recombinant CYP isoforms. Chlorpropamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 METHODS: To identify CYP isoforms(s) that catalyse 2-hydroxylation of chlorpropamide, the incubation studies were conducted using human liver microsomes and recombinant CYP isoforms. Chlorpropamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens