Title : Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.

Pub. Date : 2004 Nov

PMID : 15838264






1 Functional Relationships(s)
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1 In human ovarian xenografts, the levels of cyclooxygenase-2 protein expression were significantly reduced following treatment with the endothelin-A receptor selective antagonist, atrasentan, compared with untreated mice. Atrasentan prostaglandin-endoperoxide synthase 2 Homo sapiens