Pub. Date : 2005 May
PMID : 15834423
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, CtBP1 blocks the accessibility of p300 to histones in an NADH-sensitive manner and thus represses p300-mediated histone acetylation and transcriptional activation. | NAD | C-terminal binding protein 1 | Homo sapiens |
| 2 | In addition, an NADH-nonresponsive, monomeric mutant, CtBP1 (G183V), was found to strongly repress p300-mediated transcriptional activation. | NAD | C-terminal binding protein 1 | Homo sapiens |
| 3 | Thus, the dissociation of NADH from CtBP1 leads to the repression of p300-driven general transcriptional activity by CtBP1. | NAD | C-terminal binding protein 1 | Homo sapiens |