Pub. Date : 2005 Sep
PMID : 15828019
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. | Polyamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | To search for new approaches to limit cartilage damage, we investigated the requirement of polyamines for NF-kappaB activation by TNFalpha in human C-28/I2 chondrocytes, using alpha-difluoromethylornithine (DFMO), a specific polyamine biosynthesis inhibitor. | Polyamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | To search for new approaches to limit cartilage damage, we investigated the requirement of polyamines for NF-kappaB activation by TNFalpha in human C-28/I2 chondrocytes, using alpha-difluoromethylornithine (DFMO), a specific polyamine biosynthesis inhibitor. | Polyamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Our results show that the intracellular depletion of polyamines inhibits the response of chondrocytes to TNFalpha by interfering with the DNA binding activity of NF-kappaB. | Polyamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | This suggests that a pharmacological and/or genetic approach to deplete the polyamine pool in chondrocytes may represent a useful way to reduce NF-kappaB activation by inflammatory cytokines in arthritis without provoking chondrocyte apoptosis. | Polyamines | nuclear factor kappa B subunit 1 | Homo sapiens |