Title : Characterization of a novel metabolite intermediate of ziprasidone in hepatic cytosolic fractions of rat, dog, and human by ESI-MS/MS, hydrogen/deuterium exchange, and chemical derivatization.

Pub. Date : 2005 Jul

PMID : 15821046






2 Functional Relationships(s)
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1 In vitro studies using human liver microsomes have shown that the oxidative metabolism of ziprasidone is mediated primarily by CYP3A4. ziprasidone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 However, coadministration of ziprasidone with ketoconazole, a CYP3A4 inhibitor, showed only a modest increase in its exposure. ziprasidone cytochrome P450 family 3 subfamily A member 4 Homo sapiens