Title : P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.

Pub. Date : 2005 Jul

PMID : 15821041






1 Functional Relationships(s)
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1 In addition, the steady-state brain-to-plasma concentration ratio of fexofenadine was approximately 3-fold higher in Mdr1a/1b P-gp knockout mice than in wild-type mice. fexofenadine ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus