Pub. Date : 2005 Apr 1
PMID : 15814656
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 2 | PURPOSE: (-)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and multiple downstream signaling pathways in cancer cell lines. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 3 | PURPOSE: (-)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and multiple downstream signaling pathways in cancer cell lines. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 4 | PURPOSE: (-)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and multiple downstream signaling pathways in cancer cell lines. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 5 | PURPOSE: (-)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and multiple downstream signaling pathways in cancer cell lines. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 6 | Both EGCG and Poly E caused a decrease in the phosphorylated forms of EGFR and HER2 proteins, and subsequently caused a decrease in the phosphorylated forms of the extracellular signal-regulated kinase and Akt proteins. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 7 | Furthermore, when treatment was prolonged for 96 hours, 1 microg/mL of EGCG or Poly E was sufficient to inhibit growth, reduce activation of EGFR and HER2, and induce apoptosis. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |