Pub. Date : 2005 May
PMID : 15813899
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 2 | Melatonin has been shown to bind to the MT1 G protein-coupled receptor (GPCR) in MCF-7 breast cancer cells to modulate the estrogen response pathway suppressing estrogen-induced estrogen receptor alpha (ERalpha) transcriptional activity, blunting ER/DNA binding activity and suppressing cell proliferation. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 3 | Melatonin has been shown to bind to the MT1 G protein-coupled receptor (GPCR) in MCF-7 breast cancer cells to modulate the estrogen response pathway suppressing estrogen-induced estrogen receptor alpha (ERalpha) transcriptional activity, blunting ER/DNA binding activity and suppressing cell proliferation. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 4 | In these studies we have examined the effect of melatonin on the transcriptional activity of the ERalpha and other members of the steroid/thyroid hormone receptor superfamily, namely, the glucocorticoid receptor (GR) and the retinoic acid receptor alpha (RARalpha). | Melatonin | estrogen receptor 1 | Homo sapiens |
| 5 | As with the ERalpha, melatonin represses ligand (dexamethasone)-induced activation of the GR. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 6 | This effect of melatonin on ERalpha and GR is blocked by pertussis toxin (PTX) suggesting that melatonin"s actions may be mediated via a PTX-sensitive G(alphai) protein. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 7 | This effect of melatonin on ERalpha and GR is blocked by pertussis toxin (PTX) suggesting that melatonin"s actions may be mediated via a PTX-sensitive G(alphai) protein. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 8 | Expression of a dominant-positive G(alphai2) protein, with which the MT1 receptor has been shown to couple, is able to mimic the effect of melatonin on ERalpha but not RARalpha transcriptional activation in breast cancer cells. | Melatonin | estrogen receptor 1 | Homo sapiens |