Pub. Date : 2005 May
PMID : 15807851
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | This study was designed to investigate the relationship between influx of extracellular Ca(2+), activation of NFkappaB and synthesis of interleukin-8 (IL-8) following exposure of human neutrophils to subcytolytic concentrations (8.37 and 41.75 ng/ml) of the pneumococcal toxin, pneumolysin, as well as the potential of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid, to antagonize these events. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | These observations demonstrate that activation of NFkappaB and synthesis of IL-8, following exposure of neutrophils to pneumolysin are dependent on toxin-mediated influx of Ca(2+) and that these potentially harmful activities of the toxin are antagonized by docosahexaenoic acid. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |