Title : Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II.

Pub. Date : 2005 Jul 15

PMID : 15799721






2 Functional Relationships(s)
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1 Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM). Histidine thyrotropin releasing hormone Rattus norvegicus
2 Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM). Histidine thyrotropin releasing hormone Rattus norvegicus