Pub. Date : 1992 Jun
PMID : 1579589
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, we reported that human monocyte colony-stimulating factor (M-CSF) stimulates the clearance of lipoproteins containing apoB100 via both low density lipoprotein receptor-dependent and -independent pathways in target cells of M-CSF, and reduces plasma cholesterol level (Journal of Biological Chemistry, 265:12869-12875, 1990). | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 2 | Recently, we reported that human monocyte colony-stimulating factor (M-CSF) stimulates the clearance of lipoproteins containing apoB100 via both low density lipoprotein receptor-dependent and -independent pathways in target cells of M-CSF, and reduces plasma cholesterol level (Journal of Biological Chemistry, 265:12869-12875, 1990). | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 3 | Furthermore, we found a significant role of M-CSF in cholesterol metabolism of human monocyte-derived macrophages. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 4 | M-CSF enhanced not only the uptake of acetylated low density lipoprotein and oxidized low density lipoprotein in macrophages, but also the efflux of cholesterol from cholesterol-loaded macrophages. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 5 | M-CSF enhanced not only the uptake of acetylated low density lipoprotein and oxidized low density lipoprotein in macrophages, but also the efflux of cholesterol from cholesterol-loaded macrophages. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 6 | To elucidate in vivo effects of M-CSF on cholesterol efflux from tissues, we administered an intravenous injection of 3H-cholesterol (150 microCi) into WHHL rabbits 1 month before starting M-CSF treatment. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 7 | We observed an increased cholesterol efflux from tissues to plasma high density lipoprotein after M-CSF treatment when cholesterol efflux was estimated as the change in specific radioactivity of plasma high density lipoprotein-cholesterol. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 8 | We observed an increased cholesterol efflux from tissues to plasma high density lipoprotein after M-CSF treatment when cholesterol efflux was estimated as the change in specific radioactivity of plasma high density lipoprotein-cholesterol. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 9 | This result suggests that M-CSF can enhance the excretion of cholesterol from target cells of M-CSF, such as cholesterol-loaded macrophages in the arterial wall, and reduce the rate of atherogenesis. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 10 | This result suggests that M-CSF can enhance the excretion of cholesterol from target cells of M-CSF, such as cholesterol-loaded macrophages in the arterial wall, and reduce the rate of atherogenesis. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 11 | This result suggests that M-CSF can enhance the excretion of cholesterol from target cells of M-CSF, such as cholesterol-loaded macrophages in the arterial wall, and reduce the rate of atherogenesis. | Cholesterol | colony stimulating factor 1 | Homo sapiens |
| 12 | This result suggests that M-CSF can enhance the excretion of cholesterol from target cells of M-CSF, such as cholesterol-loaded macrophages in the arterial wall, and reduce the rate of atherogenesis. | Cholesterol | colony stimulating factor 1 | Homo sapiens |