Title : Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.

Pub. Date : 2005 Apr

PMID : 15793235






4 Functional Relationships(s)
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1 Increasing glucose from 5 to 20 mmol/l resulted in loss of glucose inhibition of PEPCK gene expression after 12 h. Furthermore, 24 h of incubation with 20 mmol/l glucose increased cAMP-stimulated PEPCK mRNA by approximately 40% (P < 0.05) and similarly increased glucose production. Cyclic AMP phosphoenolpyruvate carboxykinase 1 Rattus norvegicus
2 Increasing glucose from 5 to 20 mmol/l resulted in loss of glucose inhibition of PEPCK gene expression after 12 h. Furthermore, 24 h of incubation with 20 mmol/l glucose increased cAMP-stimulated PEPCK mRNA by approximately 40% (P < 0.05) and similarly increased glucose production. Cyclic AMP phosphoenolpyruvate carboxykinase 1 Rattus norvegicus
3 Chromatin immunoprecipitation studies of the endogenous PEPCK gene demonstrated an increased association of LAP with the cAMP response element of the promoter. Cyclic AMP phosphoenolpyruvate carboxykinase 1 Rattus norvegicus
4 An increased LAP/LIP ratio not only enhanced cAMP- and dexamethasone-induced PEPCK gene expression but also impaired the repressive effect of insulin. Cyclic AMP phosphoenolpyruvate carboxykinase 1 Rattus norvegicus