Pub. Date : 2005 Jan
PMID : 15786722
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK. | mevastatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | When we examined the survival signals at the time of apoptotic induction, we also observed that the administration of mevastatin had caused a remarkable decrease in the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). | mevastatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | These results suggested that mevastatin induced apoptosis when it inhibited GGPP biosynthesis and consequently decreased the level of phosphorylated ERK, which was a survival signal; moreover, at that time, there was no influence on NF-kappaB, Akt, p38, and Bcl-2. | mevastatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | These results suggested that mevastatin induced apoptosis when it inhibited GGPP biosynthesis and consequently decreased the level of phosphorylated ERK, which was a survival signal; moreover, at that time, there was no influence on NF-kappaB, Akt, p38, and Bcl-2. | mevastatin | mitogen-activated protein kinase 1 | Homo sapiens |