Pub. Date : 2005 Apr
PMID : 15784340
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aqueous solubility, apparent partition coefficient (logPapp) and catechol-O-methyltransferase (COMT, EC 2.1.1.6) inhibiting potency of entacapone and tolcapone were compared in vitro. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |
| 2 | Aqueous solubility, apparent partition coefficient (logPapp) and catechol-O-methyltransferase (COMT, EC 2.1.1.6) inhibiting potency of entacapone and tolcapone were compared in vitro. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |
| 3 | Entacapone and tolcapone inhibited equally rat striatal COMT in vitro with Ki values of 1.86 and 2.50 nM, respectively. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |
| 4 | In conclusion, entacapone and tolcapone are equally potent COMT inhibitors against rat striatal COMT in vitro. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |
| 5 | In conclusion, entacapone and tolcapone are equally potent COMT inhibitors against rat striatal COMT in vitro. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |
| 6 | After local intrastriatal administration, entacapone appeared to inhibit COMT faster and more effectively than the more lipophilic tolcapone. | entacapone | catechol-O-methyltransferase | Rattus norvegicus |