Pub. Date : 2005 Jan-Feb
PMID : 15773552
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously it was shown that thiol antioxidants are potent inhibitors of the NO-dependent induction of heme oxygenase 1 (HOX-1) gene. | Sulfhydryl Compounds | heme oxygenase 1 | Homo sapiens |
| 2 | Previously it was shown that thiol antioxidants are potent inhibitors of the NO-dependent induction of heme oxygenase 1 (HOX-1) gene. | Sulfhydryl Compounds | heme oxygenase 1 | Homo sapiens |
| 3 | However, the mechanism of HOX-1 gene down-regulation by thiol antioxidants and underlying signaling pathway remain unclear. | Sulfhydryl Compounds | heme oxygenase 1 | Homo sapiens |
| 4 | In this study we have examined, whether the scavenging of reactive oxygen and reactive nitrogen species (ROS and RNS) is the major cause for thiol-mediated suppression of the HOX-1 induction by NO. | Sulfhydryl Compounds | heme oxygenase 1 | Homo sapiens |
| 5 | Then, in order to determine, whether RNS scavenging is implicated in the HOX-1 down-regulation by thiol antioxidants, we took advantage of the capacity of suboptimal concentrations of the NO scavenger PTIO (2-phenyl-4,4,5,5-tetramethylimidazole-1-oxyl-3-oxide) to oxidize NO to nitrosating species. | Sulfhydryl Compounds | heme oxygenase 1 | Homo sapiens |