Title : Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium.

Pub. Date : 2005 Jul 1

PMID : 15769249






2 Functional Relationships(s)
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1 Inhibition of PLD caused a major decrease in the synthesis of PtdIns(4,5)P2, which could again be reversed by exogenously applied phosphatidic acid. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 This implies that localized PLD-regulated synthesis of PtdIns(4,5)P2 is essential for Dictyostelium actin function. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens