Pub. Date : 2005 Apr 28
PMID : 15763633
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of Zn2+ on the activity and conformation of cytochorome P450 3A4 (CYP3A4) were investigated. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Effects of Zn2+ on the activity and conformation of cytochorome P450 3A4 (CYP3A4) were investigated. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Zn2+ specifically inhibited the testosterone 6beta-hydroxylation activity of CYP3A4 with an IC50 value of 27 microM. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Zn2+ inhibited the CO-binding spectra of CYP3A4 reduced by NADPH-cytochrome P450 reductase (CPR) and NADPH only in the presence of b5. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Zn2+-induced conformational changes of CYP3A4 were monitored by CD and intrinsic fluorescence. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | These results suggest that the inhibitory effects of Zn2+ come from preventing the stimulation of b5 on CYP3A4 activity. | Zinc | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |